4,527 research outputs found
Reversal of terminal differentiation and control of DNA replication
DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells. We used this cellular system to analyze the interaction of cell cycle proteins with these foci in vivo. Cyclin A and cdk2, but not cyclin B1 and cdc2, were specifically localized at nuclear replication foci, just like the replication protein proliferating cell nuclear antigen. A potential target of cyclin A and cdk2 is the 34 kd subunit of replication protein A (RPA34). In contrast with the 70 kd subunit, which localizes to the foci, RPA34 was not detected at these replication sites, which may reflect a transient interaction. The specific localization of cyclin A and cdk2 at nuclear replication foci provides a direct link between cell cycle regulation and DNA replication
Quadratic deformation of Minkowski space
We present a deformation of the Minkowski space as embedded into the
conformal space (in the formalism of twistors) based in the quantum versions of
the corresponding kinematic groups. We compute explicitly the star product,
whose Poisson bracket is quadratic. We show that the star product although
defined on the polynomials can be extended differentiably. Finally we compute
the Eucliden and Minkowskian real forms of the deformation.Comment: Presented at XVII European Workshop on String Theory 2011. Padova
(Italy) September 05-09; Fortschr. Phys. 1-7 (2012
Assortativity and leadership emergence from anti-preferential attachment in heterogeneous networks
Many real-world networks exhibit degree-assortativity, with nodes of similar
degree more likely to link to one another. Particularly in social networks, the
contribution to the total assortativity varies with degree, featuring a
distinctive peak slightly past the average degree. The way traditional models
imprint assortativity on top of pre-defined topologies is via degree-preserving
link permutations, which however destroy the particular graph's hierarchical
traits of clustering. Here, we propose the first generative model which creates
heterogeneous networks with scale-free-like properties and tunable realistic
assortativity. In our approach, two distinct populations of nodes are added to
an initial network seed: one (the followers) that abides by usual preferential
rules, and one (the potential leaders) connecting via anti-preferential
attachments, i.e. selecting lower degree nodes for their initial links. The
latter nodes come to develop a higher average degree, and convert eventually
into the final hubs. Examining the evolution of links in Facebook, we present
empirical validation for the connection between the initial anti-preferential
attachment and long term high degree. Thus, our work sheds new light on the
structure and evolution of social networks
«Dir lo latà en so de romanç»
The author discusses the relationship between the two techniques of Medieval translation, the loss of Latin as the only written model and the creation of a literary language in Vulgar Latin in the 14th and 15th centuries
Theoretical view on the origin and implications of structural distortions in polyoxometalates
Structural features of polyoxometalates (POMs) —versatile inorganic clusters of academic and technological interest— are discussed in the present article. POMs are, in general, very regular structures presenting a high symmetry in most cases. Distortions are, however, important for some electronic and magnetic properties. We herein discuss some particular geometric features that are crucial for the theoretical treatment and comprehension of well-known experimental phenomena. For instance, we have been able to understand and rationalize the geometrical distortions present in molybdenum POMs. Moreover, we can affirm that these geometrical distortions are caused by a pseudo Jahn Teller effect. In what concerns NMR chemical shifts, we present a discussion on the importance of geometry for the correct description of the signals and the key role played by the interatomic distances. Finally, a study on the adsorption of Keggin clusters on silver surfaces shows how the POM structure looses its regular shape to adapt to that new situation
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